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Generalized spike-wave discharges involve a default mode network in patients with juvenile absence epilepsy : A MEG study

机译:一项针对青少年失神癫痫患者的广义尖峰波放电涉及默认模式网络:一项MEG研究

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摘要

This study uses magnetoencephalography (MEG) to examine whether cortical regions that constitute a default mode network are involved during generalized spike-wave discharges (GSWs) in patients with juvenile absence epilepsy (JAE). We studied five JAE patients for whom MEG was recorded using a 204-channel, whole-head gradiometer system. Dynamic statistical parametric mapping (dSPM) was done to estimate the cortical source distribution of GSW. The dSPM results showed strong medial prefrontal activation in all patients, with activation in the posterior cingulate and precuneus in three of five patients simultaneously or slightly after medial prefrontal activation. Furthermore, dSPM showed that the initial activation of a GSW appears in the focal cortical regions. Cortical regions that constitute a default mode network are strongly involved in the GSW process in some patients with JAE. Results also show that focal cortical activation appears at the onset of a GSW.
机译:这项研究使用脑磁图(MEG)来检查青少年失神癫痫(JAE)患者的广义尖峰波放电(GSW)期间是否涉及构成默认模式网络的皮质区域。我们研究了五名使用204通道全头梯度仪系统记录MEG的JAE患者。进行动态统计参数映射(dSPM)以估计GSW的皮质来源分布。 dSPM结果显示,所有患者均具有强烈的内侧前额叶激活,在内侧前额叶激活后,五位患者中有三位同时或稍有后扣带和前突激活。此外,dSPM显示GSW的初始激活出现在局灶皮层区域。在一些JAE患者中,构成默认模式网络的皮质区域强烈参与了GSW过程。结果还显示局灶性皮层激活出现在GSW发作时。

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